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Journal of Oncology Pharmacy Practice, Vol. 12, No. 3, 179-181 (2006)
DOI: 10.1177/1078155206069165
© 2006 SAGE Publications

Development of daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus durans

Myke R Green, PharmD

Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

Claudio Anasetti, MD

Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

Ramon L Sandin, MD

Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

Nancy E Rolfe, ARNP

Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

John N Greene, MD

Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

Daptomycin has demonstrated antibacterial activity against several antibiotic-resistant strains, including vancomycin-resistant enterococci.1 A paucity of data exists concerning in vivo development of daptomycin resistance of enterococci. We describe an allogeneic bone marrow transplant patient, who was found to have vancomycin-resistant Enterococcus durans bacteremia, which subsequently developed resistance to daptomycin.

Key Words: daptomycin • resistance • vancomycin-resistant enterococci • in vivo resistance • immuno-compromise


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